Thiotetronate
WebWe detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450–amidotransferase enzyme pair and highlights the first oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group from a chemically inert alkyl … WebJul 24, 2024 · The application of CRISPR/Cas9 system for genome editing in Streptomyces started in 2015, and since then related approaches have been tremendously developed. As shown in Table 1, diversified approaches are widely used to edit or refactor BGCs for NP drugs discovery and characterization. TABLE 1 TABLE 1.
Thiotetronate
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WebApr 10, 2024 · Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural … WebFollowing the in vivo investigation of thiotetronate assembly in Lentzea sp. and in S. thiolactonus NRRL 15439 (Havemann et al., Chem. Commun., 2024, DOI: 10.1039/c6cc09933e), the minimal set of genes required for thiolactomycin production was determined through heterologous expression and the mechanism for polyketide assembly …
WebChemical probing of thiotetronate bio-assembly Judith Havemann, Marie E. Yurkovich, Robert Jenkins, Sophia Harringer, Weixin Tao, Shishi Wen , Yuhui Sun, Peter F. Leadlay and … WebDec 14, 2016 · Abstract. Chemical ‘chain termination’ probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea …
WebThiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the b-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. WebThiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid synthesis in bacteria. Natural modifications at the C-5 dialkyl position in this molecular series result in pronounced bioactivity differences.
WebManuela Tosin Associate Professor [email protected] +44 (0)2476 5 72878 Tosin Group About Me Teaching and supervision Development of chemical probes and tools for natural product and chemical biology research. Groups at Warwick Manuela Tosin Group Responsabilities at Warwick Head of Organic Chemistry Teaching Section Affiliations
WebA genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chemical Science 2016-01-01 Journal article Show more detail. Source: Yuhui Sun Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system ... in what chronological orderWebJan 1, 2016 · Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the b-ketoacyl-acyl carrier protein … in what circuit is missouriWebOct 6, 2015 · Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the β-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. It has proved effective in in vivo infection models of Mycobacterium … only ssd or ssd and hddWebView history. Tools. α-, β-, γ-, and δ-lactones (left to right) Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common … onlyssd reviewWebApr 10, 2024 · Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the … in what chicago neighborhood is wrigley fieldWebYeo Joon Yoon, Bradley S Moore, Eunji Kim, 2015, Nature chemical biology. onlystaffWebThiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the b-ketoacyl-acyl carrier protein synthases (KASI/II) that... only ssd showing up windows 10