Webhomology model prompted exploration of the side chains at the thiazolopyridine ring C-5 position to access the ribose/solvent pocket. Potent compounds with GyrB IC50≤1 nM … Web29 Apr 2008 · WO2008137060 - THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY. Publication Number WO/2008/137060 …
Vishal Zambre en LinkedIn: Assessment of Structural Basis for ...
Web17 Aug 2024 · Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and … WebPursuing research and development in medicinal chemistry while delivering a variety of heterocyclic molecules (from milligram to multigram scale) to clients for trials in drug discovery. Passionate for research and development, enthusiastic in multidisciplinary research to discover new molecules and explore their properties. Expert in the synthesis … how many humans die a day
patents.google.com
Web11 Feb 2014 · The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1 ... Web4 Jan 2024 · This straightforward approach provided diversified novel thiazoloquinoline, thiazolopyridine, and thiazolonaphthyridine scaffolds, which can be applied as precursors … WebA series of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives were synthesized using 4-hydroxyquinolin-2(1H)-one as the starting material.Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and their neurotoxicities were measured by the rotarod test.The results of these tests demonstrated that 5-hexyloxy … howard baskin leash