WebThe objective of this study was to develop a population pharmacokinetic (PK) model for bedaquiline to describe the concentration-time data from phase I and II studies in healthy subjects and patients with drug-susceptible or multidrug-resistant tuberculosis (TB). A total of 5,222 PK observations from 480 subjects were used in a nonlinear mixed ... WebHalf-life ( t1/2) is defined as the amount of time required for the drug concentration measured in plasma (or other biological matrices) to be reduced to exactly half of its starting concentration or amount. After IV dosing, the drug concentrations in plasma decline due to both elimination and distribution [15].
Medistat Pharmacokinetics
WebHalf-life ( t1/2) is defined as the amount of time required for the drug concentration measured in plasma (or other biological matrices) to be reduced to exactly half of its … Web26 Jun 2024 · Goodness of fit statistic for slope 1 or 2, adjusted for the number of points used in the estimation. Corr_XY_Slope1 (or 2) Correlation between time (X) and effect (or log effect, for log regression) (Y) for the points used in the slope estimation. No_points_Slope1 (or 2) The number of data points included in calculation of slope 1 or 2. microcontroller betriebssystheme
Half Life Time - an overview ScienceDirect Topics
WebEdit. View history. Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion. WebThe elimination half-life (t1/2) is the time required for the Cp of the drug to decrease to 50% of an earlier value ( Box 7-1 ). The units for half-life are expressed as time (minutes, hours). ♦. The half-life of a drug can also be used to determine the time required for an infused drug to reach steady state ( Box 7-2 ). ♦. The half-life of a drug is the time required for the serum concentration to be reduced by 50%. Once the half-life of the drug is known, the time required for clearance can be estimated. Approximately 97% of the drug is eliminated by 5 halflives, while ~99% is eliminated by 7 half-lives. See more Biological half-life (also known as elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum See more • Half-life, pertaining to the general mathematical concept in physics or pharmacology. • Effective half-life See more Water The biological half-life of water in a human is about 7 to 14 days. It can be altered by behavior. Drinking … See more First-order elimination Half-times apply to processes where the elimination rate is exponential. If $${\displaystyle C(t)}$$ is the concentration of a … See more the oracle of delphi in the bible