Web3 Jan 2003 · Theophylline has a narrow therapeutic index and troublesome interactions (especially with macrolides & nicotine). N.B. PRESCRIBE BY BRAND - Be aware that oral modified release brands of theophylline and aminophylline are NOT interchangeable. All patients need to be maintained on the same brand as initally prescribed for them. WebTherapeutic drug monitoring For theophylline In most individuals, a plasma-theophylline concentration of 10–20 mg/litre (55–110 micromol/litre) is required for satisfactory …
Lithium Prescribing and Monitoring Guidelines - Dorset Formulary
WebTheophylline is an oral bronchodilator with a narrow therapeutic window, used in the treatment of conditions such as asthma and chronic obstructive pulmonary disease … WebCheck drug plasma levels: Five days after starting oral treatment. Routinely every 6–12 months. Check more regularly in older people or those with heart failure or hepatic … hepa filter for large areas
Phenytoin Drugs BNF NICE
WebConsult the BNF, manufacturer's Summary of Product Characteristics (SPC) and specialist textbooks for further information. Monitoring plasma levels Therapeutic levels of plasma-theophylline are usually between 10–20 mg/litre (55–110 micromol/litre), although lower concentrations may be effective in order to achieve satisfactory bronchodilation. WebIt is also targeted for drugs with unpredictable pharmacokinetic-pharmacodynamic relationships with dose as well as drugs with a narrow therapeutic index. Slide 4: Therapeutic Index. The therapeutic index is the ratio between the toxic dose in 50% of subjects and the therapeutic dose of a drug that is effective in 50% of patients. WebGenerally, the therapeutic phenytoin serum level is 10–20µg/ml (or 40–80 micromol/L). However, there are some cases which may be controlled with lower serum levels e.g.: some tonic clonic seizures elderly patients or those with hepatic impairment may achieve therapeutic control with drug levels below the normal range. hepa filter for mold honeywell