WebJan 30, 2014 · The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences. This variation makes it difficult to evaluate PTBP1 binding to particular sites based on sequence al … WebPTBP1 (HNRNP-I, HNRPI, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4) protein expression summary. ... PROTEIN FUNCTION; Protein function (UniProt) i. Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its o wn pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of ...
PTBP1‐targeting microRNAs regulate cancer‐specific energy …
WebPTB protein (polypyrimidine-tract-binding, also known as PTBP1/HNRNP I), functions as an alternative splice site repressor by binding preferentially to the polypyrimidine tract [19,24]. The role of PTB in alternative splicing sites has been previously connected with malignant transformation in cancer cells [25,26,27]. WebJun 14, 2024 · Ptbp1 is an RNA-binding protein and splicing regulator that is broadly expressed in non-neuronal and neuronal progenitor cells and represses neuronal-specific alternative splicing ( Boutz et al., 2007 ; Ling et al., 2016 ; Makeyev et al., 2007 ). Neural progenitor-specific deletion of Ptbp1 leads to precocious neurogenesis ( Shibasaki et al., … gryffindor aesthetic clothes
Full article: RNA methylation-related genes of m6A, m5C, and m1A ...
WebApr 13, 2024 · The function of AC006064.4–201 in chondrocytes was assessed using western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), immunofluorescence (IF) and β-galactosidase staining. The interaction between AC006064.4–201 and polypyrimidine tract-binding protein 1 (PTBP1), as well as cyclin … • Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774. • Ghetti A, Piñol-Roma S, Michael WM, Morandi C, Dreyfuss G (July 1992). "hnRNP I, the polypyrimidine tract-binding protein: distinct nuc… WebJun 14, 2024 · Reprogramming glial cells to convert them into neurons represents a potential therapeutic strategy that could repair damaged neural circuits and restore function. Recent studies show that downregulation of the RNA-binding protein PTBP1 leads to one-step conversion of Müller glia (MG) into retinal ganglion cells (RGCs) with a high efficiency. final fantasy 14 fray