Phosphopantetheine binding
WebCrystal structures of the PCP-reductase didomain reveal that phosphopantetheine binding alters the orientation of a key Asp, resulting in a productive orientation of the bound nicotinamide. This ensures that further reduction of the aldehyde product does not occur. WebMercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors By Maurício T. Tavares
Phosphopantetheine binding
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WebOct 5, 2007 · Together with docking simulations that identified a potential phosphopantetheine binding groove, the structural and functional studies reveal that the C9 specificity is a result of active site geometry and substrate ring constraints. The results lay the foundation for the design of novel aromatic polyketide natural products with different ... WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate.
WebJan 4, 2024 · Crystal structures of the PCP-reductase didomain reveal that phosphopantetheine binding alters the orientation of a key Asp, resulting in a productive orientation of the bound nicotinamide. This ensures that further reduction of the aldehyde product does not occur. Combining crystallography with small-angle X-ray scattering … WebAn object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in …
Webphosphopantetheine prosthetic group in the T domain to yield tyrosyl-S-NovH (Figure 2). It has been our premise that all subsequent modification steps leading to aminocoumarin … WebView publication. Phosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal ...
WebPFAM: phosphopantetheine-binding; KEGG: mxa:MXAN_2796 non-ribosomal peptide synthetase (90 aa) Predicted Functional Partners: PC1_0576. D-alanine--poly …
Web4'-Phosphopantetheine C11H23N2O7PS CID 115254 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … linksonic5 engine 2 downloadWebApr 15, 1999 · The hydrogen bond between the amide of Met74 and the carboxylic oxygen at the elbow of the pantetheine arm stabilizes the bent configuration. In the free protomer, residues 72–74 hinder binding of 4′-phosphopantetheine and would result in steric conflict between Met74 and carboxylic oxygen, thus entailing backbone movement prior to binding. linkson international ltdPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. hourly rate for .net developerWebThe P5 region is cleaved, resulting in clusters containing only fragments which are attached by the P7 region. This ensures that all copies are sequenced in the same direction. The … hourly rate for newborn nannyWebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus. Node Color colored nodes: hourly rate for nannyWebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. link sonic modWebNov 9, 1999 · The first domain (AL) shows 49% similarity to long-chain fatty acid CoA-ligases and contains a putative ATP binding box. The second and fourth domains (ACP) show 45% similarity to acyl carrier proteins, and both contain a putative 4′-phosphopantetheine binding box. The third domain (KS) is 53% similar to β-ketoacyl synthetases. links on memorial apartments portal