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Nphs1-cre

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WebTg (Nphs1-cre)33Mska Transgene Detail MGI Mouse (MGI:3762483) Search Genes More Phenotypes Phenotypes, Alleles & Diseases Query Mammalian Phenotype (MP) Browser More All MGI Reports Batch Query Genes & Markers Gene Ontology Data Gene … Web10 aug. 2024 · Crescentic glomerulonephritis encompasses a group of diverse disorders characterized by hyperplasia of parietal epithelial cells (PECs) in the space surrounding the glomerulus (so-called crescents) as the main histopathological lesion at kidney biopsy (1, 2).Crescents are frequently associated with a rapid decline in kidney function referred to …

Global polysome analysis of normal and injured podocytes

WebFlt1 allele, and the Nphs1-Cre transgene (Nphs1-Cre+Flt1ﬂox/TK). These mice can express full-length Flt1 as well as sFlt1 in all tissues except podocytes, in which the ﬂoxed allele is inacti-vated,leavingonlyFlt1TK.Outof33animalsthatwereexamined, the majority (n … Web1 mei 2009 · In all cells of the podocyte lineage in Nphs1-Cre/ROSA26 mice, the lacZ marker gene is irreversibly activated after Cre-mediated excision by nephrin promoter activation.Thus, podocyte lineage cells are theoretically stably labeled with lacZ, even when they are injured and lose podocyte markers. rao last name origin

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Web27 aug. 2024 · Nephrotic syndrome (NS) encompasses a triad of clinical features including proteinuria (≥3 g/24 h), low serum albumin (hypoalbuminemia), and edema, and is often accompanied by complications such as secondary hyperlipidemia, thrombotic events, … WebArticle “Nphs 1-Cre/ROSA26-loxP genetic podocyte tagging revealed parietal cell proliferation in p21 deficient mice with experimental nephropathy with FSGS” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, … WebThe NPHS1 gene, mapped at chromosome 19q13.1, encodes nephrin, a podocyte protein. Nephrin and podocin may interact directly or indirectly and are important for maintenance of the glomerular ... raol

Figure S1 - An Essential Role of the Universal Polarity Protein, …

Frontiers Genetic Deletion of Emp2 Does Not Cause Proteinuric …

Web(A) Kidney sections from Tjp1flox/flox and Nphs1-Cre: Tjp1flox/flox mice were examined with the antibody against Tjp1. Tjp1 was specifically eliminated from podocytes, while it was detected in endothelial cells in the glomerulus in the Nphs1-Cre: Tjp1flox/flox mice … WebThe NPHS1 gene mutated in NPHS1 children has recently been identified. The gene codes for nephrin, a cell-surface protein of podocytes. Two mutations, named Fin-major and Fin-minor, have been found in over 90% of the Finnish patients. rao lao vietnam rao lpo

"WebThe Nphs1-Cre transgene mediates podocyte-specific recombination. (A)Podocyte-specific recombination of loxP-flanked regions mediated by the Nphs1-Cre transgene. Red triangles represent loxP sequences. (B)Specific Cre activity restricted to the glomeruli was confirmed in the kidneys of Rosa26R reporter mice carrying the Nphs1-Cre transgene. X-gal … " - Nphs1-cre

Nphs1-cre

METTL3-mediated m6A modification of TIMP2 mRNA promotes …

Web14 jan. 2009 · Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Webof Cre recombinase, they express IjBDN, which lacks its N-terminal of 54 amino acids including 2 phosphorylation sites at serines 32 and 36, thereby continuously inhibiting NF-jB activation as a super-repressor. In the present study, podocyte-speciﬁc IjBDN …

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Web8 jul. 2024 · INTRODUCTION. Heparan sulphate (HS) is a linear polysaccharide that consists of glucuronic acid or iduronic acid linked to N-acetylglucosamine (GlcNAc) [ 1 ]. In our body, HS is present on the cell surface and in the extracellular matrix as heparan … Web21 mrt. 2024 · NPHS1 (NPHS1 Adhesion Molecule, Nephrin) is a Protein Coding gene. Diseases associated with NPHS1 include Nephrotic Syndrome, Type 1 and Familial Nephrotic Syndrome.Among its related pathways are Cell junction organization and …

Webdevelopment of slit diaphragms [22] and Nphs1-Cre-mediated recombination cannot be accomplished before the onset of slit diaphragm formation (data not shown). At P7–10, however, we observed apically dislocated slit diaphragms and foot process effacement. … WebNphs1‐Cre+Flt1flox/TK 33 (8/25) 24 (6‐10 weeks of age) Table S2. sFLT1 Binds to Ganglioside Extracted from Podocytes, as Measured by MRM Mass Spectrometry, Related to Figure 5

WebNphs1-Cre+Flt1flox/flox Reorganization of podocyte cytoskeleton, Kidney failure (35) Vegfr-1/Flt-1 germline TM domain knockout Flt-1TM-TK/TM-TK Reduced vascular development, death at E8.5 in some embryos (21) Vegfr-2/Flk-1 germline knockout with lacZ reporter Flk-1−/− (Flk-1lcz/lcz) Lack of vascular development, lethality at E8.5-9.5 (14 ... WebTo create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world. …

WebThe Nphs1-Cre transgene mediates podocyte-specific recombination. (A)Podocyte-specific recombination of loxP-flanked regions mediated by the Nphs1-Cre transgene. Red triangles represent loxP sequences. (B)Specific Cre activity restricted to the glomeruli was …

WebJ-GLOBAL ID：200902212109484333 整理番号：08A0528537 Nphs1-Cre/ROSA26-loxP遺伝学的有足細胞標識は,FSGSを伴う実験的腎症のp21欠失マウスにおいて壁細胞増殖を示した rao lv gramWebCre 蛋白是一种重组酶，是causes recombination的缩写，于1981 年从 P1 噬菌体中被发现，属于 λInt 酶超基因家族。 Cre 重组酶基因编码区序列全长1029bp，编码 38kDa 蛋白质，Cre 重组酶是由 343 个氨基酸组成的单体蛋白。 dr. natalya rodionova do mdWeb18 jan. 2024 · Nphs1-RiboTag and Nphs1-RiboTag-NEP25 mice without LMB2 showed a normal UACR of 0.085 mg/mg [95% confidence interval (CI) 0.076–0.096] and normal renal morphology. Glomeruli were isolated from Nphs1-RiboTag mice, homogenized, and … dr. natalya rodionova bronxNephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of … Meer weergeven Nephrin has been shown to interact with: • CASK, • CD2AP, • CDH3 and • CTNND1, • FYN, Meer weergeven • Podocyte Meer weergeven • nephrin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven • Tryggvason K (2002). "Nephrin: role in normal kidney and in disease". Adv. Nephrol. Necker Hosp. 31: 221–34. PMID 11692461. • Kestilä M, Lenkkeri U, Männikkö … Meer weergeven dr natalya avanesova njWebNS in Newborns and Children Nephrin is a podocyte protein and a major component of the SD. Mutations in the nephrin gene (NPHS1) causes congenital nephrotic syndrome of the Finnish type (CNF, NPHS1), which is an autosomal recessive disease accounting for about half of cases with congenital NS. dr natalya rodionova bronx nyWeb15 jun. 2024 · Inducible, podocyte-specific Epb41l5 knockout (KO) mice (Epb41l5 fl/fl *Nphs1-rtTA-3G*tetOCre) were generated using a previously described Epb41l5 fl/fl allele in combination with a podocyte-specific, inducible Cre line (Nphs1-rtTA-3G (syn. NEFTA)). … dr. natalya rodionovaWebTjp1 flox/flox, Tjp2 flox/flox and Nphs1-Cre mice, which drive Cre recombinase expression in podocytes under nephrin promoter, were described previously. The podocyte-specific ZO-2 knockout mice were obtained by crossing Tjp2 flox/flox mice and Nphs1-Cre : Tjp2 … dr natalya rodionova ny