Nettet2. jul. 2008 · Thrombocytopenia (TCP) is a known risk factor (RF) associated with linezolid, most often manifesting after 2 weeks of therapy. 1, 2 The rate of TCP was 2.4% (range 0.3% to 10%) in clinical trials; 1 however, post-marketing surveillance revealed an incidence of TCP [defined variably as platelet (PLT) counts of ≤100 000 to ≤150 … Nettet29. des. 2016 · Thrombocytopenia is generally defined as platelet counts <150 × 10 9 /L and represents a common laboratory finding in intensive care unit (ICU) patients. Up to 50% of patients present with thrombocytopenia at some time point of their ICU stay, and 5% to 20% develop severe thrombocytopenia, defined as platelet counts <50 × 10 9 …
How does the antibiotic linezolid (Zyvox) cause …
Nettet26. apr. 2024 · Thrombocytopenia is the most common adverse effect of linezolid treatment. Studies have shown that a linezolid trough concentration of >7–8 mg/L is associated with an increased risk of thrombocytopenia. This often limits its clinical use and may lead to discontinuation of treatment [ 1 ]. Nettet2. apr. 2024 · Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, despite concerns regarding clinical utility and growing resistance. Linezolid (LZD) affords superior tissue penetration to VCM or DAP and has been successfully used as salvage therapy for … gauck family livestock
Linezolid-induced thrombocytopenia in impaired renal function: is …
Nettet14. aug. 2014 · Thrombocytopenia (TP) is a common adverse effect of linezolid (LZD). However, risk factors for LZD-associated TP have been reported in Western patients with relatively heavy body weight. The aim of this study was to determine the risk factors for LZD-associated TP in Asian population. Materials and methods NettetUnfortunately, linezolid has been associated with causing both anemia and thrombocytopenia.(2-5) Specifically, the current FDA approved product insert warns … Nettet29. okt. 2024 · After the wide use of linezolid (LZD), numerous reports of uncontrolled studies have suggested that LZD is associated with high rates of thrombocytopenia. … dayes george east