Irf4 and b cell
WebThe transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal center …
Irf4 and b cell
Did you know?
WebMar 19, 2024 · To determine the transcriptional targets controlled by IRF4, we next performed ChIP-seq analysis in TL-Om1 cells. Given that both IRF4 and NF-κB are aberrantly activated in ATL cells, we hypothesized that IRF4 may cooperate with NF-κB in ATL cells, and hence performed ChIP-seq analysis for p65, one of the major subunits of NF-κB, in the … WebDec 1, 2024 · The overexpression of MUM1 is often activated by IRF4 rearrangement which was mainly reported in multiple myeloma [5] and was first reported in B-cell lymphoma in 2011(2).Immunohistochemical staining of MUM1 was positive in 50%–70% of LBCLs, while the incidence of IRF4 rearrangement in LBCL originating from Waldeyer’s ring is only 8% [6 …
WebApr 11, 2024 · A notable characteristic of type 2 immunity is that the initiation of the allergic response requires repeated exposures to the allergen. This contrasts with type 1 immunity, where a single infection is sufficient to drive a full-fledged immune response. One possible reason for this difference is that microbial antigens “replicate ... WebIn B cells, IRF-4 exerts its effects by interacting with PU.1 and binding to specific motifs in the enhancers of the light chain genes. B cells are present in normal numbers in …
WebApr 4, 2024 · IRF4 is highly expressed in B cells and plasma cells where it plays essential roles in controlling B cell to plasma cell differentiation and immunoglobulin class switching. Overexpression of IRF4 is found in MM patients' derived cells, often as a result of activating mutations or translocations, where it is required for their survival. WebCox univariate regression analysis revealed 45, 33, and eleven prognostic genes in the three data sets, respectively. Five common prognostic genes were revealed, including LCP2, TNFRSF9, FUT8, IRF4, and TLE1, among which LCP2, FUT8, and TLE1 were novel prognostic genes. Conclusion: Five prognostic genes of DLBCL were identified in this study.
WebIRF4 is a member of the interferon regulatory factor (IRF) family of transcription factors and exerts critical functions in various cell types of the immune system (De Silva et al., 2012).In the B cell lineage, IRF4 is expressed in all developmental stages, with the exception of germinal center (GC) B cells (Falini et al., 2000; Cattoretti et al., 2006).
WebB cells require IRF4 to mediate chronic transplant rejection. IRF4 ablation in B cells abrogates allogeneic B cell responses and may also inhibit the ability of B cells to prime … how to create grades in canvasWebInterferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene,.IRF4 functions as a key regulatory transcription factor in the … how to create grading in civil 3dWebHere we examined the role of IRF4 in transplant rejection and acceptance. We found that all fully MHC-mismatched heart allografts survived indefinitely in Irf4-deficient mice.This stable engraftment in Irf4-deficient recipients involved the progressive establishment of effector CD4 + T cell dysfunction. Mechanistically, IRF4 repressed a group of previously defined … how to create grades in excelWebNov 22, 2024 · IRF4 is also required in B cells for germinal center formation and plasma cell differentiation ( 14 – 16 ). Because of IRF4’s unique role in mature B cells, we … microsoft security bug barWebApr 26, 2024 · Author summary EBV is an important cause of human B-cell malignancies and transforms B cells in vitro. Although there are two different types of EBV (T1 and T2), most research has been performed using T1 strains and much less is known about how T2 EBV interacts with B cells. T2 EBV is most frequently found in regions of Africa where … how to create gradient mesh in photoshopWebApr 8, 2024 · These cells showed a downregulation of Pax5 compared to other B cells. Within Blimp-1 + IRF4 + B cells, IgM-, IgG-, and IgA-expressing cells were identified and immunoglobulin-class distribution was clearly different between the anatomical locations, with IgA + PCs dominating in lung tissue and IgM + PCs dominating in the spleen. … how to create gradient in excelWebMay 16, 2013 · The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation. Its differing concentrations appear to … microsoft security bulletin kb4886670