TīmeklisIntroduction. Hepatocellular carcinoma (HCC) is the sixth-most common malignant tumor worldwide, and approximately 600,000 new cases are diagnosed each year. 1 HCC is highly malignant and progresses rapidly. In addition, due to the lack of methods for early diagnosis, approximately 70% of patients will relapse or have metastases within 5 … Tīmeklis2024. gada 14. nov. · Recently, we observed that over 70% of HCC tissues were weak or negative for PD-L1 expression [].To evaluate the effect of EZH2 on PD-L1 expression, we used different hepatoma cell lines treated with IFNγ, which is a potent PD-L1 induction factor in multiple tumors [34, 35].As shown in Fig. 1c, hepatoma cells …
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TīmeklisHepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third most common cause of cancer-related deaths (1, 2).Most HCC patients are … Tīmeklis2024. gada 20. janv. · Background and objectives: EZH2 is overexpressed in hepatocellular carcinoma (HCC) and is correlated with poor prognosis. However, its … cnn slanted reporting
EZH2 promotes hepatocellular carcinoma progression through …
Tīmeklis(EZH2), a polycomb repressive complex 2 protein, is an important repressor of NK group 2D (NKG2D) ligands and regulator of NK cell-mediated eradication of HCC cells. Collectively, these studies reveal a function of EZH2 in regulating the ability of NK cells to eradicate HCC cells and suggest t hat EZH2 might function, in part, Tīmeklis2024. gada 9. janv. · IFN-γ induces up-regulation of galectin-9 and EZH2 in HCC cell lines. Galectin-9 is a target of miR-22 and EZH2 facilitates galectin-9 expression by … TīmeklisMethods Immunohistochemistry and multiplex immunofluorescence staining were performed to analyze the expression and correlation of EZH2 and PD-L1 in HCC tissues. Immunoblotting, quantitative real-time PCR, flow cytometry, chromatin immunoprecipitation, and dual-luciferase reporter gene assays were performed to … cnn slash their tires