Chloral hydrate metabolite
WebDue to the prolonged half-lives of the chloral hydrate's metabolites, excessive CNS depression may occur due to accumulation following repeated dosing. The degree of sedation should be monitored and caregivers cautioned against exceeding prescribed dosage. Neonates should be monitored for increased bilirubin concentrations as WebMetabolite Identification; Common Name: Chloral hydrate: Description: Chloral hydrate is a sedative and hypnotic drug as well as a chemical reagent and precursor. The name chloral hydrate indicates that it is formed from chloral (trichloroacetaldehyde) by the addition of one molecule of water. Its chemical formula is C2H3Cl3O2.
Chloral hydrate metabolite
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WebThe importance of enterohepatic recirculation in the kinetics of chloral hydrate metabolites has been examined by Merdink et al. (1999) through comparison between intact and bile-cannulated rats given chloral … WebPhysician reviewed chloral hydrate patient information - includes chloral hydrate description, dosage and directions. ... For sedation prior to a procedure: 25 mg/kg. …
WebChloral hydrate has been implicated in modifying responses to the oral anticoagulants dicumarol and warfarin. Another metabolite of chloral hydrate, trichloroacetic acid, may … WebFeb 15, 2024 · Because the active metabolite of chloral hydrate has a long half-life, other sedative-hypnotics are preferred for long-term use during breastfeeding, especially while nursing a neonate or preterm infant. Monitor the infant for excessive drowsiness. Drug Levels Maternal Levels.
WebJun 3, 2024 · Medical Definition of Chloral hydrate. Chloral hydrate: A prescription sedative/hypnotic drug developed in the 19th century. The drug acts rapidly and induces … WebMar 26, 2007 · The Broward County medical examiner found that Anna Nicole Smith had "high" amounts of chloral hydrate metabolites in her system. Not high enough on their own to be necessarily lethal, but high. What is the significance of her having other medicines on board? Ativan, Klonopin and Valium are all central nervous system depressants. So is …
WebInactive drug to active metabolite (chloral hydrate --> trichloroethanol) Nontoxic drug to toxic metabolite (this is lethal synthesis; we don't want this) (parathion --> paroxon)-Antifreeze is an example of this. Sites of Biotransformation. Liver (most important) Nervous tissue Kidney GI tract
Web(1988) described the determination of trichloroethylene metabolites, including chloral hydrate, in rat liver homogenate. The method was based on selective thermal conversion of chloral hydrate into chloroform, which is determined using head-space-GC with ECD. Liquid chromatographic methods have been developed for the determination of chloral ... egpu imac 2012WebChloral hydrate is rapidly converted to an active metabolite (trichloroethanol) responsible for its sedative properties, which has a half-life at therapeutic doses of up to 66 hours in … egpu imac 5kWebSep 1, 1993 · Its major metabolite, chloral hydrate, widely used as a sedative in both adults and children, is in danger of being banned by comparable studies. This paper assesses the safety of chloral hydrate. Design. Analysis of the literature regarding the metabolic, toxicologic, and epidemiologic data on trichloroethylene and chloral hydrate. egpu case macbook proWebSmall, but variable amounts of chloral hydrate metabolized to trichloroacetic acid (inactive metabolite) in liver and kidneys. Elimination Route. Active and inactive metabolites are slowly and variably excreted in the kidneys. Trichloroethanol glucuronide (urochloralic acid), an inactive metabolite, may be secreted into the bile and excreted in ... te gustariaWebNov 3, 2024 · A 25 year-old woman with a history of depression was found by her flatmate. An empty 200mL bottle of chloral hydrate was present at the scene. She arrived at your emergency department with the following vital signs: T 36.0 C P 140 /min BP 80/50 mmHg RR 14 /min SO2 93% on 15 L/min O2 via a non-rebreather mask GCS3 with pin-point pupils egpu komputronikWebChloral hydrate and its primary metabolite, trichloroethanol, competitively inhibit alcohol-metabolizing dehydrogenases, elevating alcohol blood concentrations (see Table 11-3). This combination, known colloquially as a “Mickey Finn” or “knock-out drops,” can induce severe alcohol intoxication with stupor, coma, or death. te gustaronte gustan meaning