Asebia mice
Web12 lug 2002 · To investigate whether SCD-1 might mediate some of leptin's metabolic effects, we studied asebia mice (ab J /ab J), which carry mutations in SCD-1 (17, 18).The weight of male ab J /ab J mice was indistinguishable from that of littermates, and femaleab J /ab J mice weighed significantly more than littermates (Fig. 2A, P < 0.005 at all ages … WebThe most obvious initial application of asebia mice was the analysis of skin lipids, and ab skin was shown to be deficient in esterified sterol and waxes, but overproportionally rich in free sterols, suggesting a fundamental defect in fatty acid metabolism in the epidermis (7). In addition, asebia mice were later employed
Asebia mice
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Web1 nov 2001 · These "asebia" mice are characterized by the presence of dry flaky skin and severe alopecia resulting from sebocyte atrophy, underscoring a critical role for SCD1 in sebocyte development (12,13,34 ...
WebAlthough stratum corneum (SC) hydration has been primarily of concern to the cosmetic industry, it serves an important biosensor function. In murine models, not only deiminated products of filaggrin-derived amino acids (“NMF”) but also endogenous glycerol from circulation into the epidermis via aquaporin 3 channel and from triglyceride turnover in … WebAbia sericea can reach a length of 10–12 millimetres (0.39–0.47 in). [3] The adults have a large body with a showy metallic green-golden or bronze abdomen. The thorax is black, with bluish sheen and it is slightly hairy. …
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebOverall VAS of pruritus correlated positively with age in both males (Pearson r=0.2540, p <0.0001) and females (Pearson r=0.2141, p <0.0001). Because pruritus can be associated with epidermal function, which declines after age 50 years, next we analyzed the prevalence and VAS of pruritus in patients aged ≤50 vs compared to those >50 years old.
Web1 nov 2001 · The mutant ''asebia'' mouse exhibits hair loss and scarring alopecia associated with markedly hypoplastic sebaceous glands ( Stenn, 2001 ). Data reported …
WebStearoyl-CoA desaturase (SCD) catalyzes the de novo biosynthesis of oleate and palmitoleate, which are the major fatty acids found in triglycerides, cholesteryl esters, and phospholipids. A high carbohydrate (lipogenic) diet induces lipogenic gene expression by sterol regulatory element binding protein 1 (SREBP-1c)-mediated gene transcription, … baronesa urbanovaWebSummary. The asebia mouse has chronic epidermal cell hyperproliferation. The epidermal labelling index (LI) for asebia was more than double that for BALB/cJ mic bar one savannah gaWeb1 mag 2003 · Asebia J1 mice showed normal permeability barrier homeostasis and extracellular lamellar membrane structures, but they displayed epidermal hyperplasia, … barones dalfsenWeb9 mar 2015 · First described as an alopecic spontaneous mutant mouse line lacking sebaceous glands in a publication in Science in 1965 by Allen H. Gates and Marvin … suzuki rmx 49cc precio nuevaWebThe asebia mouse represents a spontaneous mutation in BALB/c mice leading to hyperplasia of the epidermis and chronic inflammatory dermal changes including … baronesha supermarketWeb16 feb 2015 · First described as an alopecic spontaneous mutant mouse line lacking sebaceous glands in a publication in Science in 1965 by Allen H. Gates and Marvin … barone sgadari gangiWeb1 gen 2024 · Since asebia mice have inflammatory cells infiltration, especially mast cells, one report used asebia mice to evaluate the anti-inflammatory effects of CsA, especially against mast cells. After treatment with CsA in asebia mice, the number of mast cells decreased 4.5-fold in a dose-dependent manner. suzuki rmx 450 z supermoto