WebSep 15, 2024 · For each AID cell line, we performed PRO-seq under auxin-treated (6 h after treatment) and control conditions, each with two independent replicates, which showed an overall good agreement (pairwise Pearson-correlation coefficients (PCC) > 0.95 between replicates; Figure S2A). WebJan 1, 2015 · Direct genomic uracil quantification in B cell lymphoma cell lines. • Correlation of AID expression and genomic uracil. • Direct evidence for DNA-cytosine deamination by AID in cells. • AID mutational signatures in kataegis regions in B-cell malignancies. • Base excision repair and cell doubling time modulate genomic uracil content. Abstract
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WebDec 3, 2024 · The OCT4-AID-degron cell line would be the perfect system to examine this question and should avoid a lot of secondary effects that may occur even at 24 hours DOX treatment in the ZHBTc4 cell. This is a good point. Importantly, it is not straightforward to directly compare the effect of changes in chromatin accessibility of the different ... WebNov 2, 2024 · We had previously demonstrated that TAS-114, a small-molecule inhibitor of dUTPase, can significantly enhance the antitumor activity of 5-FU in various preclinical models. 20 TAS-114 can specifically modulate aberrant base incorporation into DNA in cancer cells when TS is inhibited by 5-FU, and inhibition of dUTPase plays a crucial role … million dollar baby abigail crib
Generation of auxin inducible degron (AID) knock-in cell …
WebThe Minnesota AIDSLine is Minnesota's statewide information and referral service that can answer your questions about HIV & link you to help. WebJan 23, 2008 · AID transcription was monitored with RT-PCR in a control cell line, Jurkat, and in a Jurkat-AID cell line stably transfected with AID. A Burkitt lymphoma cell line … WebMar 15, 2006 · The arrows in A indicate an extrafollicular area containing numerous AID + cells. These AID-expressing cells are large and often display a distinct dendritic … million dollar baby 2004 trailers and clips